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Research

 

To cope with DNA damage, cells rely on various activities that maintain the integrity of genetic information. Our group is interested in understanding how this is achieved on a molecular level. Our interest in the mechanisms that maintain genome stability is largely focused on a group of proteins known as SNF2 ATPases, which are known to regulate a variety of nuclear functions. The biological relevance of this protein family is highlighted by the fact that many SNF2 ATPases have been directly linked with human disease and cancer. We employ a combination of in vivo and in vitro approaches in our research, including biochemistry, cell biology, structural biology and mouse genetics. Our aim is to gain insight into the molecular basis of fundamental biological mechanisms that preserve genome integrity.